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Summary via ACC.org ScienceDaily / Adelaide University

Indeed, eGFR values were greater in patients on tirzepatide compared to those on insulin glargine, with a mean eGFR decline rate of 1.4 ml/min/1.73 m 2 per year in tirzepatide users and a between-group difference in eGFR reduction of 2.2 ml/min/1.73 m 2 per year [49]

The timing of administration matters: evening dosing (30-60 minutes before sleep) capitalizes on the natural nocturnal GH pulse, potentially producing a synergistic effect with endogenous GH secretion